Tempered enthusiasm

Tempered enthusiasm for fecal transplantation?

TO THE EDITOR—We read the case report by Solari et al [1] with great interest because the authors presented a fatal case of relapsing Clostridium difficile infection treated with fecal microbiota transplantation (FMT) using a gastrojejunostomy tube. This tube was placed through an already existing gastric feeding tube, and the patient died 4 days later due to septic shock; Pseudomonas aeruginos...

Thrombolysis in cardiac arrest: Initial enthusiasm tempered.

We read with great interest the comprehensive review advocating thrombolysis during cardiopulmonary resuscitation conducted by Professor Mysiak and co-workers [1]. However, we feel obliged to mention that an important contribution in this field was made last year. At the World Congress of Cardiology 2006 in Barcelona, the eagerly awaited results of the Thrombolysis in Cardiac Arrest (TROICA) tr...

Enthusiasm: it's catching.

Tuning tempered transitions

The method of tempered transitions was proposed by Neal (1996) for tackling the difficulties arising when using Markov chain Monte Carlo to sample from multimodal distributions. In common with methods such as simulated tempering and Metropolis-coupled MCMC, the key idea is to utilise a series of successively easier to sample distributions to improve movement around the state space. Tempered tra...

Tempered stable and tempered infinitely divisible GARCH models

In this paper, we introduce a new GARCH model with an infinitely divisible distributed innovation, referred to as the rapidly decreasing tempered stable (RDTS) GARCH model. This model allows the description of some stylized empirical facts observed for stock and index returns, such as volatility clustering, the non-zero skewness and excess kurtosis for the residual distribution. Furthermore, we...